Embryo development research published in National Academy of Sciences


Michael Gelbart, a PhD student in the Harvard Intelligent Probabilistic Systems group, publishes research on fruit fly embryo development in the Proceedings of the National Academy of Sciences. As an undergraduate at Princeton University working in the Wieschaus and Kaschube labs, Michael created Embryo Development Geometry Explorer (EDGE), a software package for automatically analyzing and reconstructing microscope images of developing embryos. Using EDGE in conjunction with state-of-the-art imaging techniques, the research team quantified individual cell shape changes over time and proposed a physical model for nucleus movement during Drosophila gastrulation. The article is available freely online through PNAS open access and is to appear soon in the print journal. EDGE is currently in use by several labs around the world including at MIT and the Max Planck Institute for Dynamics and Self-Organization in Germany. EDGE is free and open source.